The Church of Panagia Kapnikarea (Εκκλησία της Παναγίας Καπνικαρέας) is one of the oldest churches in Athens. It is located on the heart of the cty along an important shopping street. In 1834, after Greece had regained its independence and Athens, as the new capital, was in the midst of rebuilding, town planners had resolved to either demolish or relocate the church to ensure a thoroughfare for horse and carriages. The church had caught the eye of King Louis of Bavaria (father of the newly appointed King Otto of Greece) as an important landmark and together with the Metropolitan Bishop of Athens, ensured the street was designed with the church in place.

The church of Panagia Kapnikarea is a small Byzantine church dating from the 11th century. It was erected on an old church of the 5th century, itself built on a Greek temple. The church now belongs to the University of Athens and is also d "Church of the Sacred University".

The church’s name is linked with the family name “Kapnikares” and refers to the official charged with collecting tax on tobacco during the Byzantine period. It was formerly known as “Kamoucharea” from the word “kamoucha”, which means fabrics that are interwoven with gold, referencing the many textile workshops in the area.