Sint-Alexiusbegijnhof (St. Alexius Beguinage) is an oasis of quietness in the heart of Dendermonde. It has 61 houses around a green trapezium-shaped courtyard with a chapel in the middle.

The beguinage was built in 1288 and has been occupied ever since. At one time two hundred and fifty beguines, members of a religious sisterhood, lived here; the last died in 1975. Her former home houses a museum of folklore. To keep the memory of the beguines alive, one small house has been furnished as an authentic beguine's home.

Since the year of 1998 the Sint-Alexiusbegijnhof is a UNESCO World Heritage site.