The history of the Monastery of Molyvdoskepastos goes back in the Byzantine era and was originally built in the 7th century. It is one of the oldest monasteries in Greece. Its founder was the Byzantine emperor Constantine IV Pogonatos. The monastery was renovated in the 14th century by Andronikos Komnenos Doukas Palaiologos. The monastery owes its name from the lead roof it once had: i>molivdoskepasti means “with a roof of lead”. The lead was stolen by Turks to make bullets and was then replaced by slates.

The katholikon (main church) belongs to a complex architectural style and was built in three phases. The original church with three vaults and a dome, was the first to built (11th and 12th century). The middle cross vaulted section was added at the end of the 13th century and in the beginning of the 14th century. Finally, an open narthex was added in the year of 1521 by the inhabitants of a nearby village. The interior of the church is decorated with splendid wall and ceiling paintings of the 14th and 16th centuries. The iconostasis is carved, probably dating back to the 15th century with remarkable icons.

After 1913 the monastery remained without monks, its properties were encroached and its holy artifacts and relics were stolen. In 1943, when the area was bombarded by the Nazis, it was almost razed to the ground. In 1988 the monastery was manned once more by the present day brotherhood.

From the outside the monastery looks (a little bit) like a fortress, due to its walls and gatehouse. It is located about 20 km from the town of Konitsa, some hundred meters away from the Aoos River and the border with Albania.