The region of Ioannina has been popoulated by Greeks since the Mycenaean era. However the city of Ioannina - often called Yannena - was formally founded by the Byzantine Emperor Justinian in the 6th century AD.

Ioannina flourished following the Fourth Crusade, when many wealthy Byzantine families fled to the city in the early 13th century following the sack of Constantinople. It was part of the Despotate of Epirus from 1358 to 1416, before surrendering to the Ottomans in 1430. Between 1430 and 1868 the city was the administrative center of the Pashalik of Yanina. In the period between the 18th and 19th centuries, the city was a major center of the modern Greek Enlightenment. Ioannina became again part of Greece in 1913 following the Balkan Wars.

The City has a longstanding tradition in commerce and handicraft activities dating back in the 17th century, where merchants from Ioannina traded with important European commercial centers, such as Venice and Livorno, and established commercial and banking houses. During the 18th century, every author of the Greek world, was either from Ioannina or was a graduate of one of the city's schools, and the city created the reputation of being number one City in education.

Ioannina is situated on the western shore of Lake Pamvotis. Nowadays it is the capital and largest city of the region of Epirus with a population of more than 100.000 people. The city has a wealth of attractions and museums with most attractions. The main sight is the “castle” located in the center of the town, this was the heart of the Despotate of Epirus, and the Ottoman vilayet. The (historic) centre of Ioannina offers small traditional shops and houses, and many souvenir shops.