The Hogar Virgen de los Reyes is located in the La Macarena district of Seville, specifically at Avenida Doctor Fedriani, block 9, and Fray Isidoro de Sevilla 1. The building was reconstructed in 1958 and was originally known as the Hogar de San Fernando para niñas. The architect responsible for its design was Antonio Delgado Roig.

The building was initially used as a residential facility-serving as a hospicio (orphanage) and hospital. It was managed and staffed in its early years by nuns from the Order of Charity. The structure still retains the layout typical of such institutions, with rooms, cells, and large halls dedicated to its original functions.

Today, the Hogar Virgen de los Reyes is a large municipal complex devoted to educational and social assistance purposes. It occupies most of a city block and continues to play a significant role in community support and services in Seville.

The building is notable for its considerable size and institutional architecture. It includes a former chapel, which has been deconsecrated and now serves as a multipurpose hall for events and workshops. The chapel maintains its original Latin cross shape and contains remnants such as confessionals, kneelers, and wooden pews, reflecting its religious past.

The Hogar Virgen de los Reyes is also known in local legend for reported paranormal phenomena. There have been accounts of ghostly sightings, particularly of a nun said to haunt the old choir of the chapel. Other unexplained occurrences include mysterious noises, voices, and apparitions, adding a layer of mystery to the building’s history.