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Glen Coe (Scottish Gaelic: Gleann Comhann) is a glen of volcanic origins, in the Highlands of Scotland. It lies in the north of Argyll, close to the border with Lochaber. It is often considered one of the most spectacular and beautiful places in Scotland, and is a part of the designated National Scenic Area of Ben Nevis and Glen Coe. The narrow glen shows a grim grandeur. The glen, approaching from the east on the main A82 road, is surrounded by wild and precipitous mountains. Further west at Invercoe, the landscape has a softer beauty before the main entrance to the glen. The main settlement is the nearby village of Glencoe located at the foot of the glen. near the site of the 1692 Massacre of Glencoe.

The first and second companies of the Earl of Argyll's Regiment of Foot, which consisted of approximately 120 men under the command of Captain Robert Campbell of Glenlyon, were billeted on the MacDonalds in Glencoe, who received them in the hospitable tradition of the Highlands.

Early in the morning of 13 February 1692 a massacre took place in Glen Coe, in the Highlands of Scotland. This incident is referred to as the massacre of Glencoe, or in Scottish Gaelic Mort Ghlinne Comhann, or murder of Glen Coe. The massacre began simultaneously in three settlements along the glen—Invercoe, Inverrigan, and Achnacon—although the killing took place all over the glen as fleeing MacDonalds were pursued. Thirty-eight MacDonalds from the Clan MacDonald of Glencoe were killed by the guests who had accepted their hospitality, on the grounds that the MacDonalds had not been prompt in pledging allegiance to the new monarchs, William and Mary. Another forty women and children died of exposure after their homes were burned.

Memory of this massacre has been kept alive by continued ill feeling between MacDonalds and Campbells. Since the late 20th century the Clachaig Inn, a hotel and pub in Glencoe popular with climbers, has had a sign on its door saying "No Hawkers or Campbells" although it has been said that this is probably more for the amusement of tourists than from any lasting sense of revenge.

The entrance to the glen from above is on Rannoch Moor to the east, below the mountain of Meall a' Bhuiridh; Glen Etive runs to the south from nearby. The entrance to Glen Coe is marked by Buachaille Etive Mor, "the great herdsman of Etive" (left of picture) at the 'junction' with Glen Etive. Glen Coe then runs roughly west for about 12 km (7.5 mi) before turning north-west towards Loch Leven.

The Glen is named after the River Coe which runs through it. The name of the river is believed to predate the Gaelic language, and its meaning is not known. It is possible that the name stems from an individual personal name, Comhan (genitive Comhain).