In the 8th century, Arab-Moorish armies advanced into the north of the Iberian Peninsula, but as early as the 10th century the area was temporarily reconquered by the Christians (Reconquista). In the late 11th century, Count Pedro Ansúrez made the largely depopulated city his residence, expanded it, and promoted its repopulation (repoblación), which is why he is often considered the actual founder of the city. The University of Valladolid was founded in 1241 by Alfonso VIII of Castille. It is one of the oldest universities in the world.

In the 15th century, it became the capital of the Kingdom of Castile until Philip II moved the center of power to the newly built monastery residence Real Sitio de San Lorenzo de El Escorial near Madrid in 1561. In 1561 most of the city burned down but was rebuilt under Philip II.
The Colegio de San Gregorio was formerly a university and now houses the “Museo Nacional de Escultura”. This building is one of the best examples of the architectural Gothic style known as Isabelline.
The University of Valladolid was founded in the 13th century by Alfonso X ("the Wise"). This also meant that over time so-called "colegios" /colleges emerged alongside or in connection with the university.

So this colegio was founded as a teaching institution. As a theological college for Dominican monks. With papal approval, work began in 1488. The construction of the college was probably completed in 1496. The college accommodated around 20 students at a time.

The main facade is spectacular. By its stylistic features, it sets regarding the workshop of Gil de Siloé, a Flemish-origin artist, who was at that time in Burgos dealing with the royal sepulchers of the Miraflores Charterhouse.

The upper part of the facade