Slot Zeist (Castle Zeist) was built between 1677 and 1686 on behalf of Willem Adriaan van Nassau, grandson of Willem van Oranje. The building was designed by architect Jacobus Roman, who also designed Paleis Het Loo in Apeldoorn. The interior was mainly designed by the Huguenot Daniël Marot. His largely preserved wall and ceiling paintings are reminiscent of French Baroque.

In 1745, Slot Zeist was purchased by the merchant Cornelis Schellinger. In 1746, he donated part of it to the Moravian Brethren community, which would serve as their headquarters in the Netherlands.

In 1924, the castle was purchased by the municipality of Zeist. The castle was renovated in 1969 and restored to its original Baroque style, using authentic demolition material from other Baroque buildings.