The Byzantine Church of Panagia Vlacherna (Virgin Mary Church) is one of the most important Byzantine monuments of the medieval Epirus state. Initially it was dedicated to the Assumption of Mary. The church was initially the catholicon of a women’s monastery. Nowadays it serves at the parish church of the settlement of Vlacherna.

The church is built atop a middle-byzantine era basilica (late 9th – early 10th century). The central arch of which consists as an arch of the current church. In the early 13th century the Vlacherna Church was built as three-aisled wooden roof basilica, which a few years later was transformed into the vaulted type with the addition of the domes. In the second half of the 13th century the narthex was added on the west side.

The nave has important frescoes from the mid 13th century, while the frescoes in the narthex are from the end of the same century. The marble relief iconostasis is of remarkable craftsmanship.