Palazzo Piccolimini is one of the earliest examples of Renaissance architecture and was built starting in 1459 to a design by Bernardo Rossellino and commissioned by Pope Pius II
The Duomo is one of the earliest designed in the Renaissance manner. The bell tower has a Germanic flavor.
Construction started about 1459. Pope Pius II consecrated the Duomo on 29 August 1462, during his long summer visit.