Not much is known about the origins of Huis Vennebroek (Manor Vennebroek). From 1689 to 1747 the house had the so-called right of havezate (manor or fortified house). In 1768 the manor was mentioned in an advertisement in a local newspaper. In 1848, Jonkheer Hooft van Iddekinge rebuilt the house extensively, retaining a large part of the basement and the ground floor.

In 1912 the estate was bought by P.A. Camphuis, a merchant from Groningen. He was also the owner of the adjacent Friesche Veen estate; Vennebroek and Friesche Veen have formed a unit ever since. Camphuis restored the house, but did not stay there long. The manor remained in the family for a long time; the wife of his eldest son lived there until her death in 1994.

Around 1985 the house and the estates became the property of Natuurmonumenten (Society for preservation of nature monuments in the Netherlands). Since 2014 the house has been privately owned and inhabited again.

Huis Vennebroek is surrounded by a horseshoe-shaped moat. The estate has many old beeches and chestnuts; the oldest is more than 300 years. In the autumn the estate is known for its many species of mushrooms.